Protein Family Models

The HIRAN domain (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. The HIRAN domain is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes [1]. It has been predicted that this domain functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks [1] [1]. 16627993. The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA. Iyer LM, Babu MM, Aravind L;. Cell Cycle. 2006;5:775-782. (from Pfam)

Date:

2024-10-16

HIRAN (HIP116, Rad5p N-terminal) domain-containing protein is a DNA-binding protein similar to Lactobacillus plantarum protein Lp_0118

Date:

2021-02-12