Protein Family Models

Date:

2024-08-14

Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1]. [1]. 11952907. Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus. McIver KS, Myles RL;. Mol Microbiol 2002;43:1591-1601. (from Pfam)

Date:

2024-10-16

This family includes helix-turn-helix domains in a wide variety of proteins. (from Pfam)

Date:

2024-08-14

The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site [1]. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR) [1,2]. It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 16376935. Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. Anantharaman V, Aravind L;. J Mol Biol. 2006;356:823-842. [2]. 18844374. Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli. Garces F, Fernandez FJ, Gomez AM, Perez-Luque R, Campos E, Prohens R, Aguilar J, Baldoma L, Coll M, Badia J, Vega MC;. Biochemistry. 2008;47:11424-11433. (from Pfam)

Date:

2024-10-16

Involved in osmolarity control regulation

Date:

2022-05-11

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Date:

2024-04-17