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ROK family protein
This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif. (from Pfam)
ROK family transcriptional regulator
NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains an ArsR family winged helix-turn-helix domain; siimlar to Caldicellulosiruptor sp. xylose repressor, a transcriptional repressor of xylose-utilizing enzymes
sugar metabolism global transcriptional regulator Mlc
Mlc (making large colonies), a ROK family transcriptional regulator, is a global regulator of sugar metabolism, involved in stimulating glucose utilization and suppressing use of other sugars when glucose is available for rapid growth. A protein-protein interaction between Mlc and the glucose PTS transporter PtsG and sequester and inactivate Mlc.
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