Protein Family Models

Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport [1]. [1]. 10694977. Analysis of the proteome of Mycobacterium tuberculosis in. silico.. Tekaia F, Gordon SV, Garnier T, Brosch R, Barrell BG, Cole ST;. Tuber Lung Dis 1999;79:329-342. (from Pfam)

Date:

2024-08-14

Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer [1]. [1]. 12374972. Crystal structure of bacterial multidrug efflux transporter. AcrB.. Murakami S, Nakashima R, Yamashita E, Yamaguchi A;. Nature 2002;419:587-593. (from Pfam)

Date:

2024-08-14

efflux RND (Resistance-Nodulation-Cell Division) transporter permease subunit similar to the multidrug efflux pump subunit AcrB, which is a component of AcrA-AcrB-AcrZ-TolC drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates

Date:

2019-07-31

Gene:

acrB

Date:

2020-10-26

Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of Pfam HMM PF00873.

Date:

2024-06-24

Multidrug efflux RND transporter permease subunits that belong to this family include OqxB, AcrB, AcrD, AcrF, MdtF, AdeE, AdeJ, MexB, etc.

Date:

2022-10-11