Protein Family Models

This family of trans-2-enoyl-CoA reductases, EC:1.3.1.44, carries the the catalytic sites of the enzyme, characterised by the conserved sequence motifs: YNThhhFxK, and YShAPxR. In Euglena where the enzyme has been characterised it catalyses the reduction of enoyl-CoA to acyl-CoA in an unusual fatty acid pathway in mitochondria. the whole path performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. [1]. 15569691. Mitochondrial trans-2-enoyl-CoA reductase of wax ester fermentation from Euglena gracilis defines a new family of enzymes involved in lipid synthesis. Hoffmeister M, Piotrowski M, Nowitzki U, Martin W;. J Biol Chem. 2005;280:4329-4338. (from Pfam)

Date:

2024-10-16

This family carries the region of the enzyme trans-2-enoyl-CoA reductase, EC:1.3.1.44, which binds NAD(P)H. The activity of the enzyme was characterised in Euglena where an unusual fatty acid synthesis path-way in the mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The binding site is conserved as GA/CSpGYG, where p is any polar residue [1]. [1]. 15569691. Mitochondrial trans-2-enoyl-CoA reductase of wax ester fermentation from Euglena gracilis defines a new family of enzymes involved in lipid synthesis. Hoffmeister M, Piotrowski M, Nowitzki U, Martin W;. J Biol Chem. 2005;280:4329-4338. (from Pfam)

Date:

2024-10-16

This family carries the region of the enzyme trans-2-enoyl-CoA reductase, at the very C-terminus, that binds to FAD. The activity was characterised in Euglena where an unusual fatty acid synthesis path-way in mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The conserved region is seen as the motif FGFxxxxxDY [1]. [1]. 15569691. Mitochondrial trans-2-enoyl-CoA reductase of wax ester fermentation from Euglena gracilis defines a new family of enzymes involved in lipid synthesis. Hoffmeister M, Piotrowski M, Nowitzki U, Martin W;. J Biol Chem. 2005;280:4329-4338. (from Pfam)

Date:

2024-10-16

Gene:

fabV

Date:

2023-10-21

trans-2-enoyl-CoA reductase (TER) family protein such as enoyl-[acyl-carrier-protein] reductase FabV and trans-2-enoyl-CoA reductase, which are both involved in fatty acid synthesis

Date:

2018-05-16

FabV is one of several classes of enoyl-[acyl-carrier-protein] reductase that are only very distantly related to each other. Other classes include FabI (as in E. coli K-12), FabK, and FabL.

Gene:

fabV

Date:

2020-10-26