Protein Family Models

Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. This C1-terminal domain has a structure similar to phospholipase D. It is one of two closely related carboxy-terminal domains (C1 and C2 domains). Both the C1 and C2 domains (residues 322-502 and 503-687, respectively) consist of a sevenstranded mixed beta-sheet flanked by five alpha-helices. However, the structural topology and relative orientations of the helices to the beta-sheet in these two domains are different. The C1 and C2 domains are highly conserved in the PPK family. Some of the residues previously shown to be crucial for the enzyme catalytic activity are located in these two domains [1]. [1]. 15947782. Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis. Zhu Y, Huang W, Lee SS, Xu W;. EMBO Rep. 2005;6:681-687. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. This C2-terminal domain has a structure similar to phospholipase D. It is one of two closely related carboxy-terminal domains (C1 and C2 domains). Both the C1 and C2 domains (residues 322-502 and 503-687, respectively) consist of a sevenstranded mixed beta-sheet flanked by five alpha-helices. However, the structural topology and relative orientations of the helices to the beta-sheet in these two domains are different. The C1 and C2 domains are highly conserved in the PPK family. Some of the residues previously shown to be crucial for the enzyme catalytic activity are located in these two domains [1]. [1]. 15947782. Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis. Zhu Y, Huang W, Lee SS, Xu W;. EMBO Rep. 2005;6:681-687. (from Pfam)

Date:

2024-10-16

Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. (from Pfam)

Date:

2024-08-14

Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. [1]. 9501429. Transcription of ppk from Acinetobacter sp. strain ADP1, encoding a putative polyphosphate kinase, is induced by phosphate starvation. Geissdorfer W, Ratajczak A, Hillen W;. Appl Environ Microbiol 1998;64:896-901. (from Pfam)

Date:

2024-10-16

polyphosphate kinase catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)

Date:

2017-03-23

Members of this protein family are the enzyme polyphosphate kinase 1 (PPK1). This family is found in many prokaryotes and also in Dictyostelium. Sequences in the seed alignment were taken from prokaryotic consecutive two-gene pairs in which the other gene encodes an exopolyphosphatase. It synthesizes polyphosphate from the terminal phosphate of ATP but not GTP, in contrast to PPK2.

Gene:

ppk1

Date:

2021-04-27

Date:

2020-10-26