Protein Family Models

This family is composed of a group of bifunctional cobalamin biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape [1]. [1]. 9601028. Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution,. Thompson TB, Thomas MG, Escalante-Semerena JC, Rayment I;. Biochemistry 1998;37:7686-7695. (from Pfam)

Date:

2024-10-16

Catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP

Gene:

cobU

Date:

2021-07-23

bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase catalyzes the ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP

Date:

2024-08-26