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Glycosyl transferase family, helical bundle domain
This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate. [1]. 2199449. Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE;. J Biol Chem 1990;265:14016-14022. (from Pfam)
Glycosyl transferase family, a/b domain
anthranilate phosphoribosyltransferase
In many widely different species, including E. coli, Thermotoga maritima, and Archaeoglobus fulgidus, this enzymatic domain (anthranilate phosphoribosyltransferase) is found C-terminal to glutamine amidotransferase; the fusion protein is designated anthranilate synthase component II (EC 4.1.3.27)
anthranilate phosphoribosyltransferase catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
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