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Maf family protein
Maf is a putative inhibitor of septum formation [1] in eukaryotes, bacteria, and archaea. [1]. 8387996. Amplification of the Bacillus subtilis maf gene results in arrested septum formation. Butler YX, Abhayawardhane Y, Stewart GC;. J Bacteriol 1993;175:3139-3145. [2]. 1400224. Identification of Bacillus subtilis genes for septum placement and shape determination. Levin PA, Margolis PS, Setlow P, Losick R, Sun D;. J Bacteriol 1992;174:6717-6728. (from Pfam)
multicopy associated filamentation (Maf) family protein is involved in septum formation and also has a role as a house-cleaning NTP pyrophosphatase
Maf family nucleotide pyrophosphatase
Maf (for multicopy associated filamentation) is a large family of non-essential proteins active as nucleotide pyrophosphatases, with substrate ranges that include modified bases such as 5-methyl-UTP, pseudo-UTP, 5-methyl-CTP, and 7-methyl-GTP. Two members in Escherichia coli are YhdE (a dTTP/UTP pyrophosphatase) and YceF (m(7)GTP pyrophosphatase). The name Maf reflects an early study in Bacillus subtilis showing that overexpression causes inhibition of septum formation.
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