Protein Family Models

Copper homeostasis protein CutC was originally thought to be involved in copper tolerance in Escherichia coli, as mutation in the corresponding gene lead to an increased copper sensitivity [1]. However, this phenotype has been later reported to depend on the levels of he mRNA-interfering complementary RNA regulator MicL, which is transcribed from a promoter located within the coding sequence of the cutC gene in enterobacteria [2]. In the plant pathogen Xylella fastidiosa, this protein has been reported as specific for copper efflux [3]. The structure of this protein in the bacteria Shigella flexneri showed a monomer structure that adopts a common TIM beta/alpha barrel with eight beta strands surrounded by eight alpha-helices [4]. The human homologue of this protein, whose structure showed a potential copper-binding site, has an important role in intracellular copper homeostasis [5,6]. [1]. 7635807. Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli. Gupta SD, Lee BT, Camakaris J, Wu HC;. J Bacteriol 1995;177:4207-4215. [2]. 25030700. MicL, a new sigmaE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein. Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G;. Genes Dev. 2014;28:1620-1634. [3]. 34616378. Overexpression of mqsR in Xylella fastidiosa Leads to a Priming Effect of Cells to Copper Stress Tolerance. Carvalho IGB, Merfa MV, Teixeira-Silva NS, Martins PMM, Takita MA, de Souza AA;. Front Microbiol. 2021;12:712564. [4]. 15624211. Crystal structure of the copper homeostasis protein (CutCm) from Shigella flexne. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

Gene:

cutC

Date:

2021-09-10

copper homeostasis protein CutC is induced late during copper exposure and may be involved in modifying intracellular copper content

Date:

2015-08-10