Protein Family Models

Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation [1]. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 23644595. Studies of IscR reveal a unique mechanism for metal-dependent. regulation of DNA binding specificity.. Rajagopalan S, Teter SJ, Zwart PH, Brennan RG, Phillips KJ,. Kiley PJ;. Nat Struct Mol Biol. 2013;20:740-747. (from Pfam)

Date:

2024-08-14

This HMM describes IscR, an iron-sulfur binding transcription factor of the ISC iron-sulfur cluster assembly system.

Gene:

iscR

Date:

2021-09-22

Fe-S cluster assembly transcriptional regulator IscR regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins

Date:

2023-02-06

Regulates the expression of the iscRSUA operon

Gene:

iscR

Date:

2020-10-26

This HMM represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency.

Date:

2019-09-10