Protein Family Models

MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor [1]. [1]. 21908668. The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. Waters LS, Sandoval M, Storz G;. J Bacteriol. 2011;193:5887-5897. (from Pfam)

Date:

2024-10-16

Gene:

mntP

Date:

2020-10-26