Protein Family Models

This family includes Anti-CBASS protein Acb1 which which counteracts or regulates the endogenous CBASS (cyclic oligonucleotide-based antiphage signalling system) antiviral defense system. It is a phosphodiesterase that enables metal-independent hydrolysis of the cyclic di- and trinucleotide CBASS signals [1]. [1]. 35395152. Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ;. Nature. 2022;605:522-526. (from Pfam)

Date:

2024-10-16

This HMM describes an uncharacterized family of proteins found in prophage regions of a number of bacterial genomes, including Haemophilus influenzae, Xylella fastidiosa, Salmonella typhi, and Enterococcus faecalis. Distantly related proteins can be found in the prophage-bearing plasmids of Borrelia burgdorferi.

Date:

2019-09-10

DUF1073 domain-containing protein similar to Haemophilus influenzae HI_1409

Date:

2018-04-12