Protein Family Models

The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal [1]. [1]. 7851435. Characterisation of a protease from Escherichia coli involved in hydrogenase maturation. Rossmann R, Maier T, Lottspeich F, Bock A;. Eur J Biochem 1995;227:545-550. (from Pfam)

Date:

2024-10-16

HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)

Gene:

hyaD

Date:

2023-07-17

HyaD/HybD family hydrogenase maturation endopeptidase similar to Escherichia coli HybD that catalyzes the nickel-dependent cleavage of a short C-terminal peptide after a His or an Arg residue in the large subunit (pre-HybC) of hydrogenase 2| hydrogenase maturation protease similar to Thermococcus kodakarensis [NiFe] hydrogenase maturation protease HybD, which is involved in the cleavage of the C-terminal residues of [NiFe] hydrogenase large subunits by Ni recognition

Date:

2017-03-02

HycI and HoxM are well-characterized as responsible for C-terminal protease activity on their respective hydrogenase large chains. A large number of homologous proteins appear responsible for the maturation of various forms of hydrogenase.

Date:

2021-09-08

valid names: hupD, hynC, hoxM. C at 64 and 67 are believed to be metal binding. Postulated to be involved in processing or hydrogenase. Superfamily suggests that it is a peptidase/protease.

Gene:

hybD

Date:

2024-06-14