Protein Family Models

The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds. [1]. 8846223. Crystal structure of NADH oxidase from Thermus thermophilus. Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD. Nat Struct Biol 1995;2:1109-1114. [2]. 17331467. In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. de Oliveira IM, Henriques JA, Bonatto D;. Biochem Biophys Res Commun. 2007;355:919-925. (from Pfam)

Date:

2024-10-16

SagB/ThcOx family dehydrogenase such as Escherichia coli microcin B17-processing protein McbC that is necessary to process the inactive microcin B17 (McbA) precursor into the active peptide

Date:

2018-03-16

SagB of Sterptococcus pyogenes participates in the maturation of streptolysin S from a ribosomally produced precursor polypeptide. Chemically similar systems operate on highly diverse sets of bacteriocin precursors in numerous other bacteria. The cyanobactin oxidase ThcOx likewise participates in peptide modification for form a natural product. TIGR03605 describes a domain within SgaB and homologous regions from other proteins, many of which appear to be involved in biosynthesis of secondary metabolites. While some substrates may be intermediates in non-ribosomal peptide syntheses, others are involved in heterocycle-containing bacteriocin biosynthesis, and can be found near SgaC-like (see TIGR03603) and SgaD-like (see TIGR03604) proteins. Members of this domain family are heterogeneous in length, as many have a partial second copy of the domain represented here. The incomplete second domain scores below the cutoffs to this model in most cases.

Date:

2021-09-02