Protein Family Models

NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure [1]. They have roles in hemoprotein binding, heme extraction and heme transfer [2] [1]. 25153520. Molecular and evolutionary analysis of NEAr-iron Transporter (NEAT) domains. Honsa ES, Maresso AW, Highlander SK;. PLoS One. 2014;9:e104794. [2]. 25862688. Recent developments in understanding the iron acquisition strategies of gram positive pathogens. Sheldon JR, Heinrichs DE;. FEMS Microbiol Rev. 2015;39:592-630. (from Pfam)

Date:

2024-10-16

IsdC family protein

Date:

2017-03-02

Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins [1]. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, PF05031) domain which confers the ability to bind heme [2] and a C-terminal SrtB processing signal which targets the protein to the cell wall [3]. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.

Gene:

isdC

Date:

2024-05-30

Two different classes of sorting signal, both analogous to the sortase A signal LPXTG, may be recognized by the sortase SrtB. These are given as NXZTN and NPKXZ. Proteins sorted by this class of sortase are less common than the sortase A and LPXTG system. This model describes a number of cell surface protein C-terminal regions from Gram-positive bacteria that appear to be sortase B (SrtB) sorting signals.

Date:

2019-09-10