Protein Family Models

Proteins containing this zinc ribbon domain at the C-terminus include the RNA-guided DNA endonuclease TnpB, found as an accessory protein (that is, not required for transposition) in many IS (insertion sequence) elements.

Date:

2024-08-14

This family includes RNA-guided endonuclease TnpB from IS200/IS605 family elements (NF038281) and IS607 family elements (NF038280), but also many additional proteins. It exhibits homolog to or actually includes some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8. For a long time, TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.

Date:

2021-10-16

This HMM represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposases described by Pfam HMM PF01385, some type V CRISPR system effectors, and other proteins.

Date:

2021-04-27

RNA-guided endonuclease InsQ/TnpB family protein such as the RNA-guided endonuclease TnpB from IS200/IS605 family elements and IS607 family elements; this protein is homologous to some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8; TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.

Date:

2024-04-29