This entry represents a group of bacterial, fungal and plant sequences, including 2-oxoadipate dioxygenase/decarboxylase (referred to as HGLS and YdcJ) from Escherichia coli. YdcJ, which is involved in D-lysine metabolism, catalyses a successive decarboxylation and intramolecular hydroxylation of 2-oxoadipate forming 2-hydroxyglutarate in a Fe(II) and oxygen-dependent manner. Members of this protein family are thought to belong to the the vicinal oxygen chelate (VOC) superfamily [1, 2]. The structure has been solved (PDB:3iuz, PDB:6w1g). [1]. 31064836. Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in Pseudomonas putida Lysine Metabolism. Thompson MG, Blake-Hedges JM, Cruz-Morales P, Barajas JF, Curran SC, Eiben CB, Harris NC, Benites VT, Gin JW, Sharpless WA, Twigg FF, Skyrud W, Krishna RN, Pereira JH, Baidoo EEK, Petzold CJ, Adams PD, Arkin AP, Deutschbauer AM, Keasling JD;. mBio. 2019; [Epub ahead of print]. [2]. 32523014. An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism. Thompson MG, Blake-Hedges JM, Pereira JH, Hangasky JA, Belcher MS, Moore WM, Barajas JF, Cruz-Morales P, Washington LJ, Haushalter RW, Eiben CB, Liu Y, Skyrud W, Benites VT, Barnum TP, Baidoo EEK, Scheller HV, Marletta MA, Shih PM, Adams PD, Keasling JD;. Nat Commun. 2020;11:2931. (from Pfam)
GO Terms:- Molecular Function:
- oxidoreductase activity (GO:0016491)
- Date:
- 2024-10-16