Protein Family Models

One of the virulence mechanisms of E coli is the production of toxins which it produces from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to up to more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as ABC transporters (type I), type IV pili (type 2), flagella (type 3), or conjugative machines (type IV). The type VI secretion system (T6SS) is present in most pathogens that have contact with animals, plants, or humans. SciN is a lipoprotein tethered to the outer membrane and expressed in the periplasm of E coli and is essential for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation. [1]. 18805985. SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli. Aschtgen MS, Bernard CS, De Bentzmann S, Lloubes R, Cascales E;. J Bacteriol. 2008;190:7523-7531. [2]. 22184413. Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo X, Yao Y;. Infect Immun. 2012;80:1243-1251. (from Pfam)

Date:

2024-10-16

TssJ is an outer membrane lipoprotein of bacterial type VI secretion systems (T6SS).

Gene:

tssJ

Date:

2024-08-07

type VI secretion lipoprotein TssJ is an outer membrane-associated component that forms the core complex with TssL and TssM inner-membrane proteins

Date:

2020-07-02