Protein Family Models

This is a family of subunit D form various ATP synthases including V-type H+ transporting and Na+ dependent. Subunit D is suggested to be an integral part of the catalytic sector of the V-ATPase [2]. [1]. 8702544. Subunit structure and organization of the genes of the A1A0 ATPase from the Archaeon Methanosarcina mazei Go1. Wilms R, Freiberg C, Wegerle E, Meier I, Mayer F, Muller V;. J Biol Chem 1996;271:18843-18852. [2]. 7831318. A bovine cDNA and a yeast gene (VMA8) encoding the subunit D of the vacuolar H(+)-ATPase. Nelson H, Mandiyan S, Nelson N;. Proc Natl Acad Sci U S A 1995;92:497-501. (from Pfam)

Date:

2024-10-16

V-type ATP synthase subunit D is part of the catalytic core (V1) of the vacuolar (V)-type ATP synthase complex (V0/V1) that catalyzes the production of ATP from ADP in the presence of a proton gradient across the membrane

Date:

2024-06-20

Although this ATPase can run backwards, using a proton gradient to synthesize ATP, the primary biological role is to acidify some compartment, such as yeast vacuole (a lysosomal homolog) or the interior of a prokaryote.

Date:

2024-06-27