Protein Family Models

PrgU is a protein of plasmid in origin expressed mainly in Enterococcus bacteria. It forms a six beta-strand barrel with three accompanying alpha helices and is probably a homo-dimer in the cell [1]. PrgU probably acts as a RNA-binding regulator that mitigates toxicity accompanying overproduction of PrgB-like adhesins, which are involved in conjugative transfer [2]. [1]. 17302827. Specificity determinants of conjugative DNA processing in the Enterococcus faecalis plasmid pCF10 and the Lactococcus lactis plasmid pRS01. Chen Y, Staddon JH, Dunny GM;. Mol Microbiol. 2007;63:1549-1564. [2]. 27785854. PrgU: a suppressor of sex pheromone toxicity in Enterococcus faecalis. Bhatty M, Camacho MI, Gonzalez-Rivera C, Frank KL, Dale JL, Manias DA, Dunny GM, Christie PJ;. Mol Microbiol. 2017;103:398-412. (from Pfam)

Date:

2024-10-16

PrgU domain-containing protein

Date:

2017-03-02

PrgU (pheromone-responsive gene B) is behaves as a regulator, and is predicted to act as an RNA-binding protein.

Gene:

prgU

Date:

2019-08-02