Protein Family Models

This domain contains several repeats of the PQQ repeat. (from Pfam)

Date:

2024-08-14

The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilise pyrrolo-quinoline quinone as a prosthetic group. [1]. 7735834. The refined structure of the quinoprotein methanol dehydrogenase from Methylobacterium extorquens at 1.94 A. Ghosh M, Anthony C, Harlos K, Goodwin MG, Blake C;. Structure 1995;3:177-187. [2]. 8676383. Determination of the gene sequence and the three-dimensional structure at 2.4 angstroms resolution of methanol dehydrogenase from Methylophilus W3A1. Xia Z, Dai W, Zhang Y, White SA, Boyd GD, Mathews FS;. J Mol Biol 1996;259:480-501. (from Pfam)

Date:

2024-10-16

glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase, similar to Gluconobacter oxydans quinoprotein glucose dehydrogenase and Acinetobacter sp. quinate/shikimate dehydrogenase

Date:

2017-09-29

This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.

Date:

2024-06-14