Protein Family Models

This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space. [1]. 18424520. Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli. Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A;. J Bacteriol. 2008;190:4460-4469. (from Pfam)

Gene:

lptC

Date:

2024-10-16

Members of this family are LptC, a periplasmic protein tethered to the inner membrane in the lipopolysaccharide (LPS)exporter transenvelope complex (Lpt), which is responsible for conducting LPS to the outer leaflet of the outer membrane in most Gram-negative bacteria. LptC is homologous to LptA, another member of the transenvelope complex. Genes lptC and lptA are often adjacent.

Gene:

lptC

Date:

2021-04-27

LPS export ABC transporter periplasmic protein LptC interacts with LptA and the LptBFG transporter complex, and facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA

Date:

2019-05-13