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triphosphoribosyl-dephospho-CoA synthase
The citG gene is found in a gene cluster with citrate lyase subunits [1]. The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase [2-3]. [1]. 7830578. Klebsiella pneumoniae genes for citrate lyase and citrate lyase ligase: localization, sequencing, and expression. Bott M, Dimroth P;. Mol Microbiol 1994;14:347-356. [2]. 10924139. Biosynthesis of the prosthetic group of citrate lyase. Schneider K, Dimroth P, Bott M;. Biochemistry 2000;39:9438-9450. [3]. 11042274. Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group. Schneider K, Dimroth P, Bott M;. FEBS Lett 2000;483:165-168. (from Pfam)
triphosphoribosyl-dephospho-CoA synthase MdcB
This protein acts in cofactor biosynthesis, preparing the coenzyme A derivative that becomes attached to the malonate decarboxylase acyl carrier protein (or delta subunit). The closely related protein CitG of citrate lyase produces the same molecule, but the two families are nonetheless readily separated.
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