Protein Family Models for Protein (Select 896632252) - Protein Family Models

Select item 4228521.

Proteins scoring well to this HMM (> 100 bits) belong to MEROPs family M57. Members of other MEROPs families are detected, including M10 and M27, are detected with lower scores.

Date:: 2024-10-16

Family Accession:: NF023805.5
Method:: HMM

Select item 4181512.

Peptidase family M54

This is a family of metallopeptidases. Two human proteins have been reported to degrade synthetic substrates and peptides [1]. [1]. 15972818. Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea. Diaz-Perales A, Quesada V, Peinado JR, Ugalde AP, Alvarez J, Suarez MF, Gomis-Ruth FX, Lopez-Otin C;. J Biol Chem. 2005;280:30367-30375. (from Pfam)

GO Terms:

Biological Process:: proteolysis (GO:0006508)

Molecular Function:: peptidase activity (GO:0008233)

Date:: 2024-10-16

Family Accession:: NF019610.5
Method:: HMM

Select item 4109353.

matrixin family metalloprotease

The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. [1]. 7674922. Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ;. Meth Enzymol 1995;248:183-228. [2]. 7656014. The NMR structure of the inhibited catalytic domain of human stromelysin-1. Gooley PR, O'Connell JF, Marcy AI, Cuca GC, Salowe SP, Bush BL, Hermes JD, Esser CK, Hagmann WK, Springer JP, et al;. Nat Struct Biol 1994;1:111-118. (from Pfam)

GO Terms:

Molecular Function:: metalloendopeptidase activity (GO:0004222)

Biological Process:: proteolysis (GO:0006508)

Molecular Function:: zinc ion binding (GO:0008270)

Cellular Component:: extracellular matrix (GO:0031012)

Date:: 2024-10-16

Family Accession:: NF012630.5
Method:: HMM

Select item 3978424.