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bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes [1]. [1]. 9244280. Identification and characterization of an operon in Salmonella. typhimurium involved in thiamine biosynthesis.. Petersen LA, Downs DM;. J Bacteriol 1997;179:4894-4900. (from Pfam)
PfkB family carbohydrate kinase
This family includes a variety of carbohydrate and pyrimidine kinases. [1]. 9519409. Identification and characterization of an operon in Salmonella. typhimurium involved in thiamine biosynthesis.. Petersen LA, Downs DM;. J Bacteriol 1997;179:4894-4900. (from Pfam)
D-glycero-beta-D-manno-heptose-7-phosphate kinase
D-glycero-beta-D-manno-heptose-7-phosphate kinase catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate
RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in E. coli, and separate proteins in some other genome. The longer, N-terminal domain I (this family) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (TIGR02199) adds ADP to yield ADP-D-glycero-D-manno-heptose.
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