Protein Family Models

In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway [2]. [1]. 1521767. Sequence and characterization of the gcpE gene of Escherichia coli. Baker J, Franklin DB, Parker J;. FEMS Microbiol Lett 1992;73:175-180. [2]. 11274098. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. Altincicek B, Kollas AK, Sanderbrand S, Wiesner J, Hintz M, Beck E, Jomaa H;. J Bacteriol 2001;183:2411-2416. (from Pfam)

Date:

2024-10-16

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, part of an alternative non-mevalonate pathway for isoprenoid biosynthesis

Date:

2023-03-01

This model describes the IspG enzyme of the deoxyxylulose pathway (a non-mevalonate pathway) for isoprenyl pyrophosphate (IPP) biosynthesis. The model finds two forms of IspG enzyme, (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) (EC 1.17.7.1) and (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) (EC 1.17.7.3).

Gene:

ispG

Date:

2021-04-27

Catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis

Gene:

ispG

Date:

2024-12-02