Protein Family Models

Date:

2024-08-14

This entry represents the alpha-helical insertion domain of Phosphomannose isomerase type I enzymes (EC 5.3.1.8), in which the helices are packed closely, connected by short turns and loops. This domain packs closely against the catalytic domain, interrupting it [1]. [1]. 8612079. The x-ray crystal structure of phosphomannose isomerase from. Candida albicans at 1.7 angstrom resolution.. Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ,. Proudfoot AE, Bernard AR, Payton MA, Wells TN;. Nat Struct Biol 1996;3:470-479. (from Pfam)

Date:

2024-08-14

This entry represents the catalytic domain of Phosphomannose isomerase type I enzymes (EC 5.3.1.8) which contains a zinc-binding site. It is composed of beta-strands connected by long loops in a jelly roll conformation [1]. [1]. 8612079. The x-ray crystal structure of phosphomannose isomerase from. Candida albicans at 1.7 angstrom resolution.. Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ,. Proudfoot AE, Bernard AR, Payton MA, Wells TN;. Nat Struct Biol 1996;3:470-479. (from Pfam)

Date:

2024-08-14

Catalyzes the formation of of fructose 6-phosphate from mannose 6-phosphate

Gene:

manA

Date:

2021-09-20

mannose-6-phosphate isomerase catalyzes the reversible interconversion of fructose 6-phosphate and mannose 6-phosphate; belongs to the cupin superfamily

Date:

2024-09-23

The names phosphomannose isomerase and mannose-6-phosphate isomerase are synonomous. This family contains two rather deeply branched groups. One group contains an experimentally determined phosphomannose isomerase of Streptococcus mutans as well as three uncharacterized paralogous proteins of Bacillus subtilis, all at more than 50 % identity to each other, plus a more distant homolog from Archaeoglobus fulgidus. The other group contains members from E. coli, budding yeast, Borrelia burgdorferi, etc.

Gene:

manA

Date:

2024-05-30