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ATPase, T2SS/T4P/T4SS family
Members of this family include ATPases of type 2 secretion systems (T2SS), type 4 pilin (T4P, often involved in twitching motility), and type 4 secretion systems.
PilT/PilU family type 4a pilus ATPase
PilT/PilU family type 4a pilus ATPase is a hexameric ATPase that drives pilus retraction, which provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility
This model represents the PilT subfamily of proteins related to GspE, a protein involved in type II secretion (also called the General Secretion Pathway). PilT is an apparent cytosolic ATPase associated with type IV pilus systems. It is not required for pilin biogenesis, but is required for twitching motility and social gliding behaviors, shown in some species, powered by pilus retraction. Members of this family may be found in some species that type IV pili but have related structures for DNA uptake and natural transformation.
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