Protein Family Models for Protein (Select 940389175) - Protein Family Models

Select item 4149161.

DEAD/DEAH box helicase family protein

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: ATP binding (GO:0005524)

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2024-08-14

Family Accession:: NF016724.5
Method:: HMM

Select item 4141512.

DbpA RNA binding domain-containing protein

This RNA binding domain is found at the C-terminus of a number of DEAD helicase proteins [1]. It is sufficient to confer specificity for hairpin 92 of 23S rRNA, which is part of the ribosomal A-site. However, several members of this family lack specificity for 23S rRNA. These can proteins can generally be distinguished by a basic region that extends beyond this domain [Karl Kossen, unpublished data]. [1]. 10481020. Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: delineation of a novel sub-family of bacterial DEAD proteins. Kossen K, Uhlenbeck OC;. Nucleic Acids Res 1999;27:3811-3820. [2]. 12460566. The carboxy-terminal domain of the DExDH protein YxiN is sufficient to confer specificity for 23S rRNA. Kossen K, Karginov FV, Uhlenbeck OC;. J Mol Biol 2002;324:625-636. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF015817.5
Method:: HMM

Select item 4118843.

DEAD/DEAH box helicase

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)

GO Terms:

Molecular Function:: nucleic acid binding (GO:0003676)

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-10-16

Family Accession:: NF012492.5
Method:: HMM

Select item 4117614.

helicase-related protein

The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012493.5
Method:: HMM

Select item 3931765.