Protein Family Models

PE_PGRSs are a large family of Mtb proteins implicated in tuberculosis (TB) pathogenesis that show a modular structure: the N-terminal PE domain, highly homologous to the domain found in tens of others PE proteins and whose structure has been already solved by crystallography; a C-terminal domain that is unique for each protein; the polymorphic glycine-rich domain (PGRS) that varies in length from few tens to more than 1,000 amino acids [1]. [1]. 36048802. PGRS domain structures: Doomed to sail the mycomembrane. Berisio R, Delogu G;. PLoS Pathog. 2022;18:e1010760. (from Pfam)

Date:

2024-10-16

This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis [1]. The C-terminus of this domain contains the type VII secretion signal that has a YXXXD/E motif. [1]. 9634230. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jage. Nature 1998;393:537-544. [2]. 16690741. Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, Eisenberg D;. Proc Natl Acad Sci U S A. 2006;103:8060-8065. (from Pfam)

Date:

2024-10-16

PE family protein similar to various Mycobacterium tuberculosis PE and PE-PGRS (polymorphic GC-rich sequences) virulence/immunogenicity factors

Date:

2024-04-17