Protein Family Models for Protein (Select 950545346) - Protein Family Models

Select item 4233811.

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024991.5
Method:: HMM

Select item 4222762.

DNA/RNA helicase domain-containing protein

This domain is found in at the C terminus of group 3 Schlafen proteins from mammals, and represents the DNA/RNA helicase domain [2]. Schlafen proteins are involved in the control of cell proliferation, induction of immune responses, and in the regulation of viral replication [1,2,3]. These proteins inhibit DNA replication and promote cell death in response to DNA damage. They play a role in genome surveillance to kill cells with defective replication [3]. This domain is also found in various uncharacterised prokaryotic proteins fused to a DNA helicase, GIY-YIG or PD-(D/E)XK catalytic domain or HsdR-N(terminal) domain, which are similar to AAA DNA helicase, Type III restriction enzyme ATPase, RecD and RuvB helicase [3]. [1]. 23570387. The schlafen family of proteins and their regulation by interferons. Mavrommatis E, Fish EN, Platanias LC;. J Interferon Cytokine Res. 2013;33:206-210. [2]. 18355440. Subcellular localization of the Schlafen protein family. Neumann B, Zhao L, Murphy K, Gonda TJ;. Biochem Biophys Res Commun. 2008;370:62-66. [3]. 31504772. A protein architecture guided screen for modification dependent restriction endonucleases. Lutz T, Flodman K, Copelas A, Czapinska H, Mabuchi M, Fomenkov A, He X, Bochtler M, Xu SY;. Nucleic Acids Res. 2019;47:9761-9776. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF021375.5
Method:: HMM

Select item 4221643.

AAA family ATPase

Date:: 2024-08-14

Family Accession:: NF024642.5
Method:: HMM

Select item 4220214.

AAA domain-containing protein

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. (from Pfam)

GO Terms:

Molecular Function:: helicase activity (GO:0004386)

Date:: 2024-08-14

Family Accession:: NF024486.5
Method:: HMM

Select item 4217185.

AAA domain-containing protein

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024487.5
Method:: HMM

Select item 4204526.

DUF2726 domain-containing protein

This bacterial family of proteins has no known function. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF022337.5
Method:: HMM

Select item 4001767.