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Links from Protein

Items: 11

1.

Sigma-54 interaction domain

GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
regulation of DNA-templated transcription (GO:0006355)
Molecular Function:
transcription factor binding (GO:0008134)
Date:
2024-08-14

Family Accession:
NF025885.5
Method:
HMM

2.

GAF domain-containing protein

This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Discovery and naming of the GAF domain. [1]. 9433123. The GAF domain: an evolutionary link between diverse phototransducing proteins. Aravind L, Ponting CP;. Trends Biochem Sci 1997;22:458-459. [2]. 20004158. Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights. Heikaus CC, Pandit J, Klevit RE;. Structure. 2009;17:. TRUNCATED at 1650 bytes (from Pfam)

GO Terms:
Molecular Function:
protein binding (GO:0005515)
Date:
2024-10-16

Family Accession:
NF013736.5
Method:
HMM

3.

sigma 54-interacting transcriptional regulator

GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
regulation of DNA-templated transcription (GO:0006355)
Molecular Function:
transcription factor binding (GO:0008134)
Date:
2024-08-14

Family Accession:
NF012385.5
Method:
HMM

4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.
new record, indexing in progress
Family Accession:
8.
new record, indexing in progress
Family Accession:
9.
new record, indexing in progress
Family Accession:
10.

nitric oxide reductase transcription regulator

nitric oxide reductase transcription regulator similar to the Escherichia coli anaerobic nitric oxide reductase transcription regulator NorR, which is required for the expression of anaerobic nitric oxide reductase

Date:
2023-03-10

Family Accession:
11480324
Method:
Sparcle

11.

nitric oxide reductase transcriptional regulator NorR

Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon

Gene:
norR
GO Terms:
Molecular Function:
DNA-binding transcription factor activity (GO:0003700)
Biological Process:
regulation of DNA-templated transcription (GO:0006355)
Date:
2021-08-04

Family Accession:
NF003451.0
Method:
HMM

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