Protein Family Models

This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells. While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalysed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognised sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase (Swiss:Q59167), which corresponds to BcsB. [1]. 2146681. Genetic organization of the cellulose synthase operon in Acetobacter xylinum. Wong HC, Fear AL, Calhoon RD, Eichinger GH, Mayer R, Amikam D, Benziman M, Gelfand DH, Meade JH, Emerick AW, et al.;. Proc Natl Acad Sci U S A 1990;87:8130-8134. [2]. 7860585. Genes required for cellulose synthesis in Agrobacterium tumefaciens. Matthysse AG, White S, Lightfoot R;. J Bacteriol 1995;177:1069-1075. [3]. 10376842. Structural and putative regulatory genes involved in cellulose synthesis in Rhizobium leguminosarum bv. trifolii. Ausmees N, Jonsson H, Hoglund S, Ljunggren H, Lindberg M;. Microbiology 1999;145:1253-1262. (from Pfam)

Date:

2024-10-16

Gene:

bcsB

Date:

2022-02-18

cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)

Date:

2023-03-21

Gene:

bcsB

Date:

2020-10-26