Protein Family Models

RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern [1]. [1]. 12220175. YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED;. Biochemistry. 2002;41:11109-11117. (from Pfam)

Gene:

rsgA

Date:

2024-10-16

EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity

Gene:

rsgA

Date:

2021-08-24

ribosome small subunit-dependent GTPase A (RsgA) is a late-stage ribosome biogenesis factor involved in 30S subunit maturation

Date:

2023-03-14

Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option).

Gene:

rsgA

Date:

2024-05-30