Enzymes of phosphoinositide synthesis in secretory vesicles destined for the plasma membrane in Saccharomyces cerevisiae

J Bacteriol. 1990 Jul;172(7):4115-7. doi: 10.1128/jb.172.7.4115-4117.1990.

Abstract

CDP-diacylglycerol synthase, phosphatidylinositol synthase, and phosphatidylinositol kinase activities were associated with post-Golgi apparatus secretory vesicles destined for the plasma membrane of Saccharomyces cerevisiae. These results suggest that the plasma membrane is capable of synthesizing both CDP-diacylglycerol and phosphatidylinositol as well as phosphorylating phosphatidylinositol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 1-Phosphatidylinositol 4-Kinase
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
  • Cell Membrane / enzymology
  • Cytoplasmic Granules / enzymology*
  • Macromolecular Substances
  • Microsomes / enzymology
  • Molecular Weight
  • Nucleotidyltransferases / isolation & purification
  • Nucleotidyltransferases / metabolism*
  • Phosphatidylinositols / biosynthesis*
  • Phosphotransferases / metabolism*
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae Proteins*
  • Transferases (Other Substituted Phosphate Groups)*

Substances

  • Macromolecular Substances
  • Phosphatidylinositols
  • Saccharomyces cerevisiae Proteins
  • Phosphotransferases
  • 1-Phosphatidylinositol 4-Kinase
  • PIK1 protein, S cerevisiae
  • Nucleotidyltransferases
  • phosphatidate cytidylyltransferase
  • Transferases (Other Substituted Phosphate Groups)
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase