Emerging Roles of SPT5 in Transcription

Cell Physiol Biochem. 2023 Oct 23;57(5):395-408. doi: 10.33594/000000665.

Abstract

Suppressor of Ty homolog-5 (SPT5) discovered in the yeast mutant screens as a suppressor of mutation caused by the insertion of the Transposons of yeast (Ty) element along with SPT4, with which it forms a holoenzyme complex known as DRB sensitivity-inducing factor (DSIF) and plays an essential role in the regulation of transcription. SPT5 is a highly conserved protein across all three domains of life and performs critical functions in transcription, starting from promoter-proximal pausing to termination. We also highlight the emerging role of SPT5 in other non-canonical functions, such as the regulation of post-translational modifications (PTM) and the transcriptional regulation of non-coding genes. Also, in brief, we highlight the clinical implications of SPT5 dysregulation.

Keywords: Cancer; DSIF; Neurodegenerative disease; RNAP I; SPT5.

MeSH terms

  • Chromosomal Proteins, Non-Histone / metabolism
  • Nuclear Proteins* / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins* / metabolism
  • Transcription, Genetic
  • Transcriptional Elongation Factors / genetics
  • Transcriptional Elongation Factors / metabolism

Substances

  • Nuclear Proteins
  • Chromosomal Proteins, Non-Histone
  • Transcriptional Elongation Factors
  • Saccharomyces cerevisiae Proteins