Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster

Mech Ageing Dev. 1984 Mar;24(3):335-42. doi: 10.1016/0047-6374(84)90118-0.

Abstract

The molecular basis was sought for the previously observed drop in the synthesis of elongation factor one (EF-1) and subsequent decline in overall protein synthesis in aging Drosophila melanogaster. It has been found that translatable poly(A+)RNA for EF-1 disappears at about the same time that EF-1 synthesis decreases. This disappearance is specific for EF-1, since overall poly(A+)RNA levels and their translation to cellular proteins remain constant over the life-span of the organism. The disappearance of translatable RNA is not the result of a specific loss of the polyadenylate segment of poly(A+)RNA, since poly(A-)RNA exhibits a similar specific loss of translation ability for EF-1.

Publication types

  • Comparative Study

MeSH terms

  • Aging*
  • Animals
  • Drosophila melanogaster / metabolism*
  • Peptide Elongation Factor 1
  • Peptide Elongation Factors / biosynthesis*
  • Poly A / metabolism
  • Protein Biosynthesis
  • RNA, Messenger / metabolism*

Substances

  • Peptide Elongation Factor 1
  • Peptide Elongation Factors
  • RNA, Messenger
  • Poly A