Abstract
Transporters of the RND superfamily are well-known as the major drug efflux pumps of Gram-negative bacteria. However, they are widespread in organisms ranging from Archaea to Eukaryotes, and perform diverse functions. This review gives a brief overview of these diverse members of the superfamily with emphasis on their structure and functions.
Keywords:
Phylogeny; Quaternary structure; Superfamily.
Copyright © 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
MeSH terms
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Animals
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Anti-Bacterial Agents / metabolism
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Bacteria / chemistry
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Bacteria / classification
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Bacteria / genetics
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Bacteria / metabolism*
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Eukaryota / chemistry
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Eukaryota / classification
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Eukaryota / genetics
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Eukaryota / metabolism*
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Evolution, Molecular
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Humans
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Membrane Transport Proteins / chemistry
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / metabolism*
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Models, Molecular
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Multigene Family*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Membrane Transport Proteins