RND transporters in the living world

Res Microbiol. 2018 Sep-Oct;169(7-8):363-371. doi: 10.1016/j.resmic.2018.03.001. Epub 2018 Mar 22.

Abstract

Transporters of the RND superfamily are well-known as the major drug efflux pumps of Gram-negative bacteria. However, they are widespread in organisms ranging from Archaea to Eukaryotes, and perform diverse functions. This review gives a brief overview of these diverse members of the superfamily with emphasis on their structure and functions.

Keywords: Phylogeny; Quaternary structure; Superfamily.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / metabolism
  • Bacteria / chemistry
  • Bacteria / classification
  • Bacteria / genetics
  • Bacteria / metabolism*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Eukaryota / chemistry
  • Eukaryota / classification
  • Eukaryota / genetics
  • Eukaryota / metabolism*
  • Evolution, Molecular
  • Humans
  • Membrane Transport Proteins / chemistry
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism*
  • Models, Molecular
  • Multigene Family*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Membrane Transport Proteins