Various anti-cancer drugs effect on liver: time course and dose-response
Summary:
Analysis of livers of Sprague-Dawley males treated with the anticancer drug carmustine, methotrexate, or thioguanine. Animals treated daily with various doses and livers examined at various time points up to 5 days. Results combined with clinical pathology assessments in a chemogenomics database.
Ganter B, Tugendreich S, Pearson CI, Ayanoglu E et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. J Biotechnol 2005 Sep 29;119(3):219-44. PMID: 16005536
