Analysis of highly purified long-term hematopoietic stem cells from young and old C57BL/6s at 2 to 3 months and 22 to 24 months of age, respectively. Results provide insight into the cellular and molecular changes underlying hematopoietic stem cell aging.
Rossi DJ, Bryder D, Zahn JM, Ahlenius H et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 2005 Jun 28;102(26):9194-9. PMID: 15967997