Fibrosarcoma cell line response to various cytostatic drugs
Summary:
Analysis of fibrosarcoma HT1080 cells following exposure to the cytostatic chemotherapeutic agents actinomycin D or vincristine for 24 hours, or doxorubicin for 6 and 24 hours. Results provide insight into the molecular mechanisms underlying the cell death in response to cytotoxic therapies.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Lehnhardt M, Klein-Hitpass L, Kuhnen C, Homann HH et al. Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer 2005 Jul 7;5:74. PMID: 16001973
