Methyl-CpG-binding protein 2 binding disruption during neuronal maturation
Summary:
Analysis of SH-SY5Y cells undergoing PMA-induced neuronal maturational differentiation after transfection with a MeCP2 decoy to disrupt binding of MeCP2 to endogenous targets. Results provide insight into the pathogenesis of Rett syndrome, a neurodevelopmental disorder caused by mutations in MeCP2.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Peddada S, Yasui DH, LaSalle JM. Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet 2006 Jun 15;15(12):2003-14. PMID: 16682435
