CH1 domain deletion, p300 and CBP heterozygous null mutant fibroblasts response to hypoxia
Summary:
Analysis of hypoxic fibroblasts with deletions in the CH1 domains of p300 and CBP combined with a p300 or CBP allele knockout. CH1 domains interact with the C-TAD domain of hypoxia-inducible transcription factors HIF-1a and -2a. Results provide insight into the role for CH1 domains in hypoxia.
Kasper LH, Boussouar F, Boyd K, Xu W et al. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J 2005 Nov 16;24(22):3846-58. PMID: 16237459
