Rapamycin effect on a glucorticoid-resistant T cell lymphoblastic leukemia cell line: time course
Summary:
Analysis of the glucocorticoid (GC) resistant T cell lymphoblastic leukemia cell line CEM-c1 following treatment with rapamycin for 3 or 24 hours. Results compared to a GC sensitivity expression signature. Results provide insight into the feasibility of using rapamycin to reverse GC resistance.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Wei G, Twomey D, Lamb J, Schlis K et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 2006 Oct;10(4):331-42. PMID: 17010674
