Activity-dependent neuroprotective protein null mutation effect on embryos
Summary:
Analysis of E9 mutant embryos lacking the gene for the activity-dependent neuroprotective protein (ADNP). ADNP deficiency results in neural tube closure defects and death at E8.5 to E9.5. Results provide insight into the role of ADNP in embryogenesis at the molecular level.
Mandel S, Rechavi G, Gozes I. Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol 2007 Mar 15;303(2):814-24. PMID: 17222401
Hacohen-Kleiman G, Sragovich S, Karmon G, Gao AYL et al. Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. J Clin Invest 2018 Nov 1;128(11):4956-4969. PMID: 30106381
