Recycling factor p110 mutation effect on embryonic development
Summary:
Analysis of 3 and 5-day egy mutant embryos, which contain a mutation in recycling factor p110. This mutation leads to microcephaly and thymus hypoplasia. U4/U6 snRNPs are disrupted in egy mutants. Results provide insight into the mechanisms underlying these developmental defects.
Trede NS, Medenbach J, Damianov A, Hung LH et al. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6608-13. PMID: 17416673
