Proapoptotic BH3-only protein Nix deficiency effect on the spleen
Summary:
Analysis of spleens of mutants lacking Nix, a proapoptotic BH3-only factor that is transcriptionally induced during erythropoiesis. Erythropoiesis requires a critical balance between proapoptotic and antipaoptotic pathways. Results provide insight into the role of Nix in erythropoiesis.
Diwan A, Koesters AG, Odley AM, Pushkaran S et al. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6794-9. PMID: 17420462