Transcriptional regulators Bmi-1 and Mel-18 depletion effect on medulloblastoma cell line
Summary:
Analysis of DAOY medulloblastoma cells following RNAi knockdown of Bmi-1, Mel-18, or both. Bmi-1 and Mel-18 belong to the Polycomb group (PcG) of transcriptional regulators. Results provide insight into the role of Bmi-1 and Mel-18 in the pathogenesis of medulloblastoma.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Wiederschain D, Chen L, Johnson B, Bettano K et al. Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Mol Cell Biol 2007 Jul;27(13):4968-79. PMID: 17452456
