Hexose-6-phosphate dehydrogenase deficiency effect on skeletal muscles
Summary:
Analysis of skeletal muscles from animals lacking hexose-6-phosphate dehydrogenase (H6PD). H6PD null animals develop severe skeletal myopathy characterized by switching of Type II to Type I fibers. Results provide insight into the molecular basis of the myopathy induced by the absence of H6PD.
Lavery GG, Walker EA, Turan N, Rogoff D et al. Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem 2008 Mar 28;283(13):8453-61. PMID: 18222920
